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Inside-out membrane vesicles isolated from HEK293 cells.
PgP vesicles with an ATP/AMP ratio >5 are readily available from PharmTox.
PgP mediated convallatoxin (digoxin analogue) transport:

Name: MDR1, multidrug resistance protein 1, permeability glycoprotein, P-gp, ATP-binding cassette sub-family B member 1, ABCB1.
Diseases: - .
PgP substrates: convallatoxin, digoxin, N-methyl-quinidine (NMQ), colchicine, tacrolimus, quinidine, etoposide, doxorubicin, etc.
PgP is present in: Intestine, liver, kidney, blood-brain barrier, many tumor cells.
In stock: human Pgp.
Available: mouse and rat Pgp.

For ordering information or product quotes please contact PharmTox.
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