PharmTox
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Vesicular transport assaysHuman drug efflux transporters (ABC transporters) are transiently overexpressed in human embryonic kidney (HEK293) cells. Inside-out membrane vesicles are prepared from these cells and used for high-throughput applications. The transporters translocate various compounds into membrane vesicles in an ATP-dependent manner. Detection of the substrate inside the vesicles is possible with radiolabel, fluorescent or LC-MS detection. PharmTox delivers high quality large uniform batches with guaranteed transport ratios.Purposes: drug interaction studies; inhibition studies; substrate studies; pharmacokinetic studies. (click on transporter to obtain more information) |
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